High-level triclosan resistance in Pseudomonas aeruginosa is solely a result of efflux.
by
Chuanchuen R, Karkhoff-Schweizer RR, Schweizer HP.
Department of Microbiology, Immunology and Pathology,
College of Veterinary Medicine and Biomedical Sciences,
Colorado State University, USA.
Am J Infect Control. 2003 Apr;31(2):124-7.

ABSTRACT

BACKGROUND: Pseudomonas aeruginosa is intrinsically resistant to high levels of triclosan. METHODS: Using the agar incorporation method and defined mutant strains, the contribution of multidrug efflux pumps to high-level (>1,000 microg/mL) triclosan resistance in P aeruginosa was assessed. RESULTS: The results showed that the ability of P aeruginosa to survive in the presence of triclosan concentrations in excess of 1,000 microg/mL is solely attributable to the expression of efflux pumps.


Triclosan Research