Reduced triclosan
susceptibility in methicillin-resistant Staphylococcus epidermidis.
by
Schmid MB, Kaplan N.
Affinium Pharmaceuticals, Inc.,
Toronto, Ontario M5J 1V6, Canada. Antimicrob Agents Chemother. 2004 Apr;48(4):1397-9.
ABSTRACT
Triclosan MIC determination showed that recent
Staphylococcus aureus clinical isolates (n = 100) were highly
susceptible to triclosan, with a 50% minimal inhibitory concentration
(MIC(50)) of 0.12 microg/ml and a MIC(90) of 0.25 microg/ml.
Staphylococcus epidermidis isolates (n = 96) were less susceptible,
with a MIC(50) of 0.12 microg/ml and a MIC(90) of 8 microg/ml.
Decreased susceptibility to triclosan was more prevalent among
methicillin-resistant S. epidermidis than among methicillin-sensitive
S. epidermidis isolates.